Publication List - Ian A. Cook, M.D.
* Listing of selected publications with abstracts *

Full Listing:

Schrader LM, Cook IA, Miller PR, Maremont ER, Degiorgio CM.
Trigeminal nerve stimulation in major depressive disorder: First proof of concept in an open pilot trial.
Epilepsy & Behavior 2011 [epub] abstract full text

Hunter AM, Leuchter AF, Cook IA, Abrams M.
Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment.
Acta Psychiatr Scand. 2010 Dec;122(6):461-9. abstract full text

Leuchter AF, Cook IA, Hamilton SP, Narr KL, Toga A, Hunter AM, Faull K, Whitelegge J, Andrews AM, Loo J, Way B, Nelson SF, Horvath S, Lebowitz BD.
Biomarkers to predict antidepressant response.
Curr Psychiatry Rep. 2010 Dec;12(6):553-62. abstract full text

Hunter AM, Cook IA, Leuchter AF.
Impact of antidepressant treatment history on clinical outcomes in placebo and medication treatment of major depression.
J Clin Psychopharmacol. 2010 Dec;30(6):748-51. abstract

Hunter A, Bordelon Y, Cook I, Leuchter A.
QEEG Measures in Huntington's Disease: A Pilot Study.
PLoS Curr. 2010 Oct 25;2:RRN1192. abstract

Townsend JD, Eberhart NK, Bookheimer SY, Eisenberger NI, Foland-Ross LC, Cook IA, Sugar CA, Altshuler LL.
fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder.
Psychiatry Res. 2010 Sep 30;183(3):209-17. abstract

Kobak KA, Leuchter A, DeBrota D, Engelhardt N, Williams JB, Cook IA, Leon AC, Alpert J.
Site versus centralized raters in a clinical depression trial: impact on patient selection and placebo response.
J Clin Psychopharmacol. 2010 Apr;30(2):193-7. abstract

Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, John Rush A.
Do atypical features affect outcome in depressed outpatients treated with citalopram?
Int J Neuropsychopharmacol. 2010 Feb;13(1):15-30. abstract

Leuchter AF, Husain MM, Cook IA, Trivedi MH, Wisniewski SR, Gilmer WS, Luther JF, Fava M, Rush AJ.
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Psychol Med. 2010 Feb;40(2):239-51. abstract

Farahbod H, Cook IA, Korb AS, Hunter AM, Leuchter AF.
Amygdala lateralization at rest and during viewing of neutral faces in major depressive disorder using low-resolution brain electromagnetic tomography.
Clin EEG Neurosci. 2010 Jan;41(1):19-23. abstract

Leuchter AF, Cook IA, Hunter AM, Korb AS.
A new paradigm for the prediction of antidepressant treatment response.
Dialogues Clin Neurosci. 2009;11(4):435-46. abstract

Cook IA, Hunter AM, Abrams M, Siegman B, Leuchter AF.
Midline and Right Frontal Brain Function as a Physiologic Biomarker of Remission in Major Depression.
Psychiatry Res: Neuroimaging 2009 Nov 30;174(2):152-7. abstract full text

Kalechstein AD, De la Garza R 2nd, Newton TF, Green MF, Cook IA, Leuchter AF.
Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals.
J Neuropsychiatry Clin Neurosci. 2009 Summer;21(3):254-8. abstract full text

Leuchter AF, Cook IA, Gilmer WS, Marangell LB, Burgoyne KS, Howland RH, Trivedi MH, Zisook S, Jain R, Fava M, Iosifescu D, Greenwald S.
Effectiveness of a Quantitative Electroencephalographic Biomarker for Predicting Differential Response or Remission with Escitalopram and Bupropion in Major Depressive Disorder.
Psychiatry Res. 2009 Sep 30;169(2):132-8. abstract full text

Leuchter AF, Cook IA, Marangell LB, Gilmer WS, Burgoyne KS, Howland RH, Trivedi MH, Zisook S, Jain R, McCracken MT, Fava M, Iosifescu D, Greenwald S.
Comparative Effectiveness of Biomarkers and Clinical Indicators for Predicting Outcomes of SSRI Treatment in Major Depressive Disorder: Results of the BRITE-MD Study.
Psychiatry Res. 2009 Sep 30;169(2):124-31. abstract full text

Hunter AM, Muthén BO, Cook IA, Leuchter AF.
Antidepressant Response Trajectories and Quantitative Electroencephalography (QEEG) Biomarkers in Major Depressive Disorder.
J Psychiatric Res (in press) abstract full text

Hunter AM, Leuchter AF, Cook IA, Abrams M, Siegman BE, Furst DE, Chappell AS.
Brain Functional Changes and Duloxetine Treatment Response in Fibromyalgia: A Pilot Study.
Pain Med. 2009 May-Jun;10(4):730-8. abstract full text

Leuchter AF, McCracken JT, Hunter AM, Cook IA, Alpert JE.
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder.
J Clin Psychopharmacol. 2009 Aug;29(4):372-7. abstract full text

Korb AS, Hunter AM, Cook IA, Leuchter AF.
Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression.
Clin Neurophysiol. 2009 Jul;120(7):1313-9. abstract full text

Leuchter AF, Husain MM, Cook IA, Trivedi MH, Wisniewski SR, Gilmer WS, Luther JF, Fava M, Rush AJ.
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Psychol Med. 2009 Jun 3:1-13. abstract full text

Leuchter AF, Cook IA, Hunter A, Korb A.
Use of clinical neurophysiology for the selection of medication in the treatment of major depressive disorder: the state of the evidence.
Clin EEG Neurosci. 2009 Apr;40(2):78-83. abstract

Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, Rush AJ.
Do Atypical Features Affect Outcome in Depressed Outpatients Treated with Citalopram?
Int J Neuropsychpharmarcol. 2009 Apr 3:1-16. abstract full text

Hunter AM, Ravikumar S, Cook IA, Leuchter AF.
Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression.
Acta Psychiatr Scand. 2009; 119(4):266-73 abstract full ref

Korb AS, Cook IA, Hunter AM, Leuchter AF.
Brain electrical source differences between depressed subjects and healthy controls.
Brain Topogr. 2008 Dec; 21(2):138-46. abstract full ref

Cook IA.
Biomarkers in Psychiatry: Potentials, Pitfalls, and Pragmatics.
Primary Psychiatry. 2008; 15(3):54-59 abstract full ref

Lesser IM, Zisook S, Flores D, Sciolla A, Cook I, Epstein M, Rosales A, Albala AA, Gonzalez C, Trivedi M, Luther J, Alpert JE, Rush AJ.
Spanish- And English-Speaking Hispanic Patients In STAR*D: Comparison Of Outcomes.
Psychiatr Serv 59(11):1273-84. 2008. abstract full ref

Leuchter AF, Cook IA, DeBrota DJ, Hunter AM, Potter WZ, McGrouther CC, Morgan ML, Abrams M, Siegman B.
Changes in brain function during administration of venlafaxine or placebo to normal subjects.
Clin EEG Neurosci. 2008 Oct; 39(4):175-81. abstract

Shapiro D, Cook IA, Davydov DM, Ottaviani C, Leuchter AF, Abrams M.
Yoga as a Complementary Treatment of Depression: Effects of Traits and Moods on Treatment Outcome.
Evid Based Complement Alternat Med. 2007 Dec;4(4):493-502. abstract full ref

Hunter AM, Cook IA, Leuchter AF.
The Promise of the Quantitative Electroencephalogram as a Predictor of Antidepressant Treatment Outcomes in Major Depressive Disorder.
Psychiatr Clin North Am. 2007 Mar; 30(1):105-124. abstract full ref

Cook IA, Balasubramani GK, Eng H, Friedman E, Young EA, Martin J, Nay WY, Ritz L, Rush AJ, Stegman D, Warden D, Trivedi MH, Wisniewski SR.
Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder.
J Psychiatr Res. 2007 Nov; 41(9):737-43 abstract full ref

Cook IA, Bookheimer SY, Mickes L, Leuchter AF, Kumar A.
Aging and brain activation with working memory tasks: an fMRI study of connectivity.
Int J Geriatr Psychiatry. 2007 Apr; 22(4):332-42 abstract full ref

Davydov DM, Shapiro D, Cook IA, Goldstein I.
Baroreflex mechanisms in major depression.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):164-77. abstract full ref

Hunter AM, Leuchter AF, Morgan ML, Cook IA.
Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression.
Am J Psychiatry. 2006 Aug; 163(8):1426-32. abstract full ref

Morgan ML, Cook IA, Rapkin AJ, Leuchter AF.
Neurophysiologic changes during estrogen augmentation in perimenopausal depression.
Maturitas. 2007 Jan 20; 56(1):54-60 abstract full text

Moses T, Leuchter AF, Cook I, Abrams M.
Does the clinical course of depression determine improvement in symptoms and quality of life?
J Nerv Ment Dis. 2006 Apr; 194(4):241-8. abstract full text

Venneman S, Leuchter A, Bartzokis G, Beckson M, Simon SL, Schaefer M, Rawson R, Newton T, Cook IA, Uijtdehaage S, Ling W.
Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition.
J Neuropsychiatry Clin Neurosci. 2006 Spring; 18(2):208-16. abstract full text

Cook IA, Leuchter AF, Morgan ML, Stubbeman W, Siegman B, Abrams M.
Changes in prefrontal activity characterize clinical response in SSRI nonresponders: a pilot study.
J Psychiatr Res. 2005 Sep; 39(5):461-6. abstract full text

Novick JS, Stewart JW, Wisniewski SR, Cook IA, Manev R, Nierenberg AA, Rosenbaum J, Shores-Wilson K, Balasubramani GK, Biggs MM, Zisook S, Rush AJ.
Clinical and demographic features of atypical depression in outpatients with major depression: preliminary findings from STAR*D.
J Clin Psychiatry. 2005 Aug; 66(8): 1002-11. full text

Morgan M, Cook IA, Rapkin A, VanBatenburg C, Leuchter AF.
Estrogen augmentation in perimenopausal depression: a pilot study.
J Clin Psychiatry. 2005 Jun;66(6):774-80 abstract full text

Morgan ML, Witte EA, Cook IA, Leuchter AF, Abrams M, Siegman B.
Influence of Age, Gender, Health Status, and Depression on Quantitative EEG.
Neuropsychobiology. 2005 Jun 29;52(2):71-76 [Epub ahead of print] abstract full text

Morgan ML, Cook IA, Rapkin AJ, Leuchter AF.
Estrogen Augmentation of Antidepressants in Perimenopausal Depression: A Pilot Study.
J Clin Psychiatry. 2005 Jun;66(6):774-780. abstract full text

Hunter AM, Leuchter AF, Morgan ML, Cook IA, Abrams M, Siegman B, Debrota DJ, Potter WZ.
Neurophysiologic correlates of side effects in normal subjects randomized to venlafaxine or placebo
Neuropsychopharmacology 2005 Apr;30(4):792-9. epub 2004 Dec 22 [ahead of print] abstract full text

Krell HV, Leuchter AF, Morgan M, Cook IA, Abrams M.
Subject expectations of treatment effectiveness and outcome of treatment with an experimental antidepressant.
J Clin Psychiatry. 2004 Sep;65(9):1174-9. abstract full text

Stubbeman WF, Leuchter AF, Cook IA, Shurman BD, Morgan M, Gunay I, Gonzalez S.
Pretreatment neurophysiologic function and ECT response in depression.
J ECT. 2004 Sep;20(3):142-144. abstract full text

Cook IA.
Guideline watch: Practice guideline for the treatment of patients with delirium.
Arlington, VA: American Psychiatric Association. full text

Cook IA.
Guideline watch: Practice guideline for the psychiatric evaluation of adults.
Arlington, VA: American Psychiatric Association. full text

Leuchter AF, Morgan M, Cook IA, Dunkin J, Abrams M, Witte E.
Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression.
Psychopharmacology (Berl). 2004 Jul 14 abstract full text

Cook IA, Leuchter AF, Morgan ML, Dunkin JJ, Witte E, David S, Mickes L, O'Hara R, Simon S, Lufkin R, Abrams M, Rosenberg S.
Longitudinal progression of subclinical structural brain disease in normal aging.
Am J Geriatr Psychiatry. 2004 Mar-Apr;12(2):190-200. abstract full text

Newton TF, Kalechstein AD, Hardy DJ, Cook IA, Nestor L, Ling W, Leuchter AF.
Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers.
Clin Neurophysiol. 2004 Jan;115(1):194-8. abstract full text

Newton TF, Cook IA, Kalechstein AD, Duran S, Monroy F, Ling W, Leuchter AF.
Quantitative EEG abnormalities in recently abstinent methamphetamine dependent individuals.
Clin Neurophysiol. 2003 Mar;114(3):410-5. abstract full text

Kumar A, Cook IA.
White matter injury, neural connectivity and the pathophysiology of psychiatric disorders.
Dev Neurosci. 2002;24(4):255-61. abstract full text

Cook IA, Leuchter AF, Morgan ML, Conlee EW, David S, Lufkin R, Babaie A, Dunkin JJ, O'Hara R, Simon S, Lightner A, Thomas S, Broumandi D, Badjatia N, Mickes L, Mody RK, Arora S, Zheng Z, Abrams M, Rosenberg-Thompson S.
Cognitive and physiologic correlates of subclinical structural brain disease in elderly healthy control subjects.
Arch Neurol. 2002 Oct;59(10):1612-20. abstract full text

Cook IA, Morgan ML, Dunkin JJ, David S, Witte E, Lufkin R, Abrams M, Rosenberg S, Leuchter AF.
Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study.
Int J Geriatr Psychiatry. 2002 Jul;17(7):610-8. abstract full text

Cook IA, Leuchter AF, Morgan M, Witte E, Stubbeman WF, Abrams M, Rosenberg S, Uijtdehaage SH.
Early changes in prefrontal activity characterize clinical responders to antidepressants.
Neuropsychopharmacology. 2002 Jul;27(1):120-31. abstract full text

Unutzer J, Choi Y, Cook IA, Oishi S.
A web-based data management system to improve care for depression in a multicenter clinical trial.
Psychiatr Serv. 2002 Jun;53(6):671-3, 678 abstract full text

Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M.
Changes in brain function of depressed subjects during treatment with placebo.
Am J Psychiatry. 2002 Jan;159(1):122-9 abstract full text

Cook IA, Leuchter AF.
Prefrontal changes and treatment response prediction in depression.
Semin Clin Neuropsychiatry. 2001 Apr;6(2):113-20. abstract

Edwards-Lee T, Cook I, Fairbanks L, Leuchter A, Cummings JL.
Quantitative electroencephalographic correlates of psychosis in Alzheimer disease.
Neuropsychiatry Neuropsychol Behav Neurol. 2000 Jul;13(3):163-70. abstract

Dunkin JJ, Leuchter AF, Cook IA, Kasl-Godley JE, Abrams M, Rosenberg-Thompson S.
Executive dysfunction predicts nonresponse to fluoxetine in major depression.
J Affect Disord. 2000 Oct;60(1):13-23. abstract full text

Leuchter AF, Uijtdehaage SH, Cook IA, O'Hara R, Mandelkern M.
Relationship between brain electrical activity and cortical perfusion in normal subjects.
Psychiatry Res. 1999 Apr 26;90(2):125-40. abstract full text

Cook IA, Leuchter AF, Witte E, Abrams M, Uijtdehaage SH, Stubbeman W, Rosenberg-Thompson S, Anderson-Hanley C, Dunkin JJ.
Neurophysiologic predictors of treatment response to fluoxetine in major depression.
Psychiatry Res. 1999 Mar 22;85(3):263-73. Erratum in: Psychiatry Res 2000 Jul 24;95(1):87. abstract full text corrigendum

Cook IA, O'Hara R, Uijtdehaage SH, Mandelkern M, Leuchter AF.
Assessing the accuracy of topographic EEG mapping for determining local brain function.
Electroencephalogr Clin Neurophysiol. 1998 Dec;107(6):408-14. abstract full text

Cook IA, Leuchter AF, Uijtdehaage SH, Osato S, Holschneider DH, Abrams M, Rosenberg-Thompson S.
Altered cerebral energy utilization in late life depression.
J Affect Disord. 1998 May;49(2):89-99. abstract full text

Newton TF, Cook IA, Holschneider DP, Rosenblatt MR, Lindholm JE, Jarvik MM.
Quantitative EEG effects of nicotine replacement by cigarette smoking.
Neuropsychobiology. 1998;37(2):112-6. abstract full text

Leuchter AF, Cook IA, Uijtdehaage SH, Dunkin J, Lufkin RB, Anderson-Hanley C, Abrams M, Rosenberg-Thompson S, O'Hara R, Simon SL, Osato S, Babaie A.
Brain structure and function and the outcomes of treatment for depression.
J Clin Psychiatry. 1997;58 Suppl 16:22-31. abstract full text

Cook IA, Leuchter AF.
Synaptic dysfunction in Alzheimer's disease: clinical assessment using quantitative EEG.
Behav Brain Res. 1996 Jun;78(1):15-23 abstract full text

Leuchter AF, Cook IA, Mena I, Dunkin JJ, Cummings JL, Newton TF, Migneco O, Lufkin RB, Walter DO, Lachenbruch PA.
Assessment of cerebral perfusion using quantitative EEG cordance.
Psychiatry Res. 1994 Sep;55(3):141-52. abstract full text

Leuchter AF, Cook IA, Lufkin RB, Dunkin J, Newton TF, Cummings JL, Mackey JK, Walter DO.
Cordance: a new method for assessment of cerebral perfusion and metabolism using quantitative electroencephalography.
Neuroimage. 1994 Jun;1(3):208-19. abstract full text

Leuchter AF, Simon SL, Daly KA, Rosenberg-Thompson S, Abrams M, Dunkin JJ, Cook IA, Newton TF, Spar JE.
Quantitative EEG correlates of outcome in elderly geriatric patients. II. two-year follow-up of patients with depression.
Am J Geriatr Psychiatry. 1994 2:290-299.

Leuchter AF, Simon SL, Daly KA, Rosenberg-Thompson S, Abrams M, Dunkin JJ, Cook IA, Newton TF, Walter DO, Cummings JL.
Quantitative EEG correlates of outcome in elderly psychiatric patients. I. cross-sectional and longitudinal assessment of patients with dementia.
Am J Geriatr Psychiatry. 1994 2:200-209.

Leuchter AF, Dunkin JJ, Lufkin RB, Anzai Y, Cook IA, Newton TF.
Effect of white matter disease on functional connections in the aging brain.
J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1347-54. abstract

Dunkin JJ, Leuchter AF, Newton TF, Cook IA.
Reduced EEG coherence in dementia: state or trait marker?
Biol Psychiatry. 1994 Jun 1;35(11):870-9. abstract

Leuchter AF, Cook IA, Newton TF, Dunkin J, Walter DO, Rosenberg-Thompson S, Lachenbruch PA, Weiner H.
Regional differences in brain electrical activity in dementia: use of spectral power and spectral ratio measures.
Electroencephalogr Clin Neurophysiol. 1993 Dec;87(6):385-93. abstract full text

Leuchter AF, Newton TF, Cook IA, Walter DO, Rosenberg-Thompson S, Lachenbruch PA.
Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia.
Brain. 1992 Oct;115 ( Pt 5):1543-61. abstract full text DOI